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Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

Antibodies have proven to be effective agents in cancer imaging and therapy. One of the major challenges still facing the field is the heterogeneous distribution of these agents in tumors when administered systemically. Large regions of untargeted cells can therefore escape therapy and potentially s...

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Библиографические подробности
Главные авторы: Thurber, Greg M., Schmidt, Michael M., Wittrup, K. Dane
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820307/
https://ncbi.nlm.nih.gov/pubmed/18541331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2008.04.012
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