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A mechanistic compartmental model for total antibody uptake in tumors

Antibodies are under development to treat a variety of cancers, such as lymphomas, colon, and breast cancer. A major limitation to greater efficacy for this class of drugs is poor distribution in vivo. Localization of antibodies occurs slowly, often in insufficient therapeutic amounts, and distribut...

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Bibliografiske detaljer
Main Authors: Thurber, Greg M., Dane Wittrup, K.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729444/
https://ncbi.nlm.nih.gov/pubmed/22974563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2012.08.034
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