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A mechanistic compartmental model for total antibody uptake in tumors
Antibodies are under development to treat a variety of cancers, such as lymphomas, colon, and breast cancer. A major limitation to greater efficacy for this class of drugs is poor distribution in vivo. Localization of antibodies occurs slowly, often in insufficient therapeutic amounts, and distribut...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3729444/ https://ncbi.nlm.nih.gov/pubmed/22974563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2012.08.034 |
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