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No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro
CDK5/p35 is a cyclin-dependent kinase essential for normal neuron function. Proteolysis of the p35 subunit in vivo results in CDK5/p25 that causes neurotoxicity associated with a number of neurodegenerative diseases. Whereas the mechanism by which conversion of p35 to p25 leads to toxicity is unknow...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840295/ https://ncbi.nlm.nih.gov/pubmed/20133653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912718107 |
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