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p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity
Cyclin-dependent kinase 5(CDK5) in complex with its activator, p35 (protein of 35 kDa), is essential for early neurodevelopment in mammals. However, endogenous cleavage of p35 to p25 is associated with neuron death and neurodegenerative disease. Here we show that a peptide (p10′) encoding the N-term...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3523839/ https://ncbi.nlm.nih.gov/pubmed/23151508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212914109 |
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