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Severe oxidative stress induces protein mistranslation through impairment of an aminoacyl-tRNA synthetase editing site
Oxidative stress arises from excessive reactive oxygen species (ROS) and affects organisms of all three domains of life. Here we present a previously unknown pathway through which ROS may impact faithful protein synthesis. Aminoacyl-tRNA synthetases are key enzymes in the translation of the genetic...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840151/ https://ncbi.nlm.nih.gov/pubmed/20160114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000315107 |
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