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Mechanism of oxidant-induced mistranslation by threonyl-tRNA synthetase
Aminoacyl-tRNA synthetases maintain the fidelity during protein synthesis by selective activation of cognate amino acids at the aminoacylation site and hydrolysis of misformed aminoacyl-tRNAs at the editing site. Threonyl-tRNA synthetase (ThrRS) misactivates serine and utilizes an editing site cyste...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041444/ https://ncbi.nlm.nih.gov/pubmed/24744241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku271 |
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