Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI(3)kinase/AKT/Bcl-X(L) Activation and CD8(+) T Cell–mediated Tumor Eradication

To enhance the strength of activation afforded by tumor antigen-specific receptors, we investigated the effect of adding combined CD28 and 4-1BB costimulatory signaling domains to a chimeric antigen receptor (CAR) specific for prostate-specific membrane antigen (PSMA). Having transferred receptors e...

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Detalhes bibliográficos
Main Authors: Zhong, Xiao-Song, Matsushita, Maiko, Plotkin, Jason, Riviere, Isabelle, Sadelain, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839303/
https://ncbi.nlm.nih.gov/pubmed/19773745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.210
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