Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

Bruton’s tyrosine kinase (Btk) is essential for normal B lymphocyte development and function. The activity of Btk is partially regulated by transphosphorylation within its kinase domain by Src family kinases at residue Tyr-551 and subsequent autophosphorylation at Tyr-223. Activation correlates with...

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Bibliographische Detailangaben
Hauptverfasser: Li, Zuomei, Wahl, Matthew I., Eguinoa, Alicia, Stephens, Leonard R., Hawkins, Phillip T., Witte, Owen N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences of the USA 1997
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC28391/
https://ncbi.nlm.nih.gov/pubmed/9391111
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