Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

Bruton’s tyrosine kinase (Btk) is essential for normal B lymphocyte development and function. The activity of Btk is partially regulated by transphosphorylation within its kinase domain by Src family kinases at residue Tyr-551 and subsequent autophosphorylation at Tyr-223. Activation correlates with...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Li, Zuomei, Wahl, Matthew I., Eguinoa, Alicia, Stephens, Leonard R., Hawkins, Phillip T., Witte, Owen N.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28391/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391111/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13820
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