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Phosphorylation of two regulatory tyrosine residues in the activation of Bruton’s tyrosine kinase via alternative receptors

Mutation of Bruton’s tyrosine kinase (Btk) impairs B cell maturation and function and results in a clinical phenotype of X-linked agammaglobulinemia. Activation of Btk correlates with an increase in the phosphorylation of two regulatory Btk tyrosine residues. Y551 (site 1) within the Src homology ty...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wahl, Matthew I., Fluckiger, Anne-Catherine, Kato, Roberta M., Park, Hyunsun, Witte, Owen N., Rawlings, David J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23526/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9326643/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.21.11526
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