Efflux-Pump Derived Multiple Drug Resistance to Ethambutol Monotherapy in Mycobacterium tuberculosis and Ethambutol Pharmacokinetics-Pharmacodynamics

BACKGROUND: In the treatment of tuberculosis, ethambutol is used in case there is isoniazid resistance. We examined for the emergence of drug resistance to ethambutol monotherapy in pharmacokinetic-pharmacodynamic studies in the hollow fiber system. METHODS: Dose–effect studies and dose-scheduling s...

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Hauptverfasser: Srivastava, Shashikant, Musuka, Sandirai, Sherman, Carleton, Meek, Claudia, Leff, Richard, Gumbo, Tawanda
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838947/
https://ncbi.nlm.nih.gov/pubmed/20210628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/651377
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