Pharmacokinetic Mismatch Does Not Lead to Emergence of Isoniazid- or Rifampin-Resistant Mycobacterium tuberculosis but to Better Antimicrobial Effect: a New Paradigm for Antituberculosis Drug Scheduling

Multidrug resistant-tuberculosis is a pressing problem. One of the major mechanisms proposed to lead to the emergence of drug resistance is pharmacokinetic mismatch. Stated as a falsifiable hypothesis, the greater the pharmacokinetic mismatch between rifampin and isoniazid, the higher the isoniazid-...

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Hauptverfasser: Srivastava, Shashikant, Sherman, Carleton, Meek, Claudia, Leff, Richard, Gumbo, Tawanda
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195047/
https://ncbi.nlm.nih.gov/pubmed/21896907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00269-11
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