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Discovery of 2-Aminothiazoles as Potent Antiprion Compounds
Prion diseases are fatal, untreatable neurodegenerative diseases caused by the accumulation of the misfolded, infectious isoform of the prion protein (PrP), termed PrP(Sc). In an effort to identify novel inhibitors of prion formation, we utilized a high-throughput enzyme-linked immunosorbent assay (...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology (ASM)
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838138/ https://ncbi.nlm.nih.gov/pubmed/20032192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02145-09 |
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