Crystal Structure of the Cystic Fibrosis Transmembrane Conductance Regulator Inhibitory Factor Cif Reveals Novel Active-Site Features of an Epoxide Hydrolase Virulence Factor

Cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif) is a virulence factor secreted by Pseudomonas aeruginosa that reduces the quantity of CFTR in the apical membrane of human airway epithelial cells. Initial sequence analysis suggested that Cif is an epoxide hydrolase...

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Bibliografiske detaljer
Main Authors: Bahl, Christopher D., Morisseau, Christophe, Bomberger, Jennifer M., Stanton, Bruce A., Hammock, Bruce D., O'Toole, George A., Madden, Dean R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838060/
https://ncbi.nlm.nih.gov/pubmed/20118260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01348-09
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