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Active-site flexibility and substrate specificity in a bacterial virulence factor: crystallographic snapshots of an epoxide hydrolase
The CFTR inhibitory factor (Cif) is an epoxide-hydrolase virulence factor from Pseudomonas aeruginosa, with catalytic activity that perturbs essential host-defense networks. Its targets are largely unknown, but include an epoxy-fatty acid. In this class of signaling molecules, chirality can be an im...
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| Publicado no: | Structure |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5524515/ https://ncbi.nlm.nih.gov/pubmed/28392259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.03.002 |
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