Radiosynthesis of [(131)I]IAZGP via nucleophilic substitution and its biological evaluation as a hypoxia marker — is specific activity a factor influencing hypoxia-mapping ability of a hypoxia marker?

INTRODUCTION: The hypoxia marker IAZGP, 1-(6-deoxy-6-iodo-β-D-galactopyranosyl)-2-nitroimidazole, has been labeled with (123)I/(124)I/(125)I/(131)I via iodine–radioiodine exchange, which gives the radiotracer in a specific activity of 10–90 MBq/μmol. We synthesized the same radiotracer possessing se...

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Hauptverfasser: Suehiro, Makiko, Burgman, Paul, Carlin, Sean, Burke, Sean, Yang, Guangbin, Ouerfelli, Ouathek, Oehler-Janne, Christoph, O’Donoghue, Joseph, Ling, Clifton, Humm, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837594/
https://ncbi.nlm.nih.gov/pubmed/19520288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2009.03.002
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