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POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation
Telomerase contributes to chromosome end replication by synthesizing repeats of telomeric DNA, and the telomeric DNA-binding proteins protection of telomeres (POT1) and TPP1 synergistically increase its repeat addition processivity. To understand the mechanism of increased processivity, we measured...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2837173/ https://ncbi.nlm.nih.gov/pubmed/20094033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.409 |
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