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The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization
BACKGROUND: Nelfinavir is an HIV protease inhibitor that has been used for a long period of time to treat HIV-infected individuals. It has recently emerged that nelfinavir could represent a prospective new anti-cancer drug, prompting us to test the effect of nelfinavir on leukemia cells. METHODS: By...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2836985/ https://ncbi.nlm.nih.gov/pubmed/20105315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-19 |
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