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Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists

Neuroblastoma (NB) is a common, highly lethal pediatric cancer, with treatment failures largely attributable to the emergence of chemoresistance. The pro-survival Bcl2 homology (BH) proteins critically regulate apoptosis, and may represent important therapeutic targets for restoring drug sensitivity...

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Autori principali: Lestini, Brian J., Goldsmith, Kelly C., Fluchel, Mark N., Liu, Xueyuan, Chen, Niel L., Goyal, Bella, Pawel, Bruce R., Hogarty, Michael D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770183/
https://ncbi.nlm.nih.gov/pubmed/19556859
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