EGFR signaling defines Mcl(-)1 survival dependency in neuroblastoma

The pediatric solid tumor neuroblastoma (NB) often depends on the anti-apoptotic protein, Mcl(-)1, for survival through Mcl(-)1 sequestration of pro-apoptotic Bim. High affinity Mcl(-)1 inhibitors currently do not exist such that novel methods to inhibit Mcl(-)1 clinically are in high demand. Recept...

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Publicat a:Cancer Biol Ther
Autors principals: Nalluri, Srilatha, Peirce, Susan K, Tanos, Rachel, Abdella, Haneen A, Karmali, Dipan, Hogarty, Michael D, Goldsmith, Kelly C
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622539/
https://ncbi.nlm.nih.gov/pubmed/25756510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2014.1002333
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