Sorafenib-Induced Apoptosis of Chronic Lymphocytic Leukemia Cells Is Associated with Downregulation of RAF and Myeloid Cell Leukemia Sequence 1 (Mcl-1)

We have previously shown that sorafenib, a multikinase inhibitor, exhibits cytotoxic effects on chronic lymphocytic leukemia (CLL) cells. Because the cellular microenvironment can protect CLL cells from drug-induced apoptosis, it is important to evaluate the effect of novel drugs in this context. He...

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Autores principales: Fecteau, Jessie-F, Bharati, Ila S, O’Hayre, Morgan, Handel, Tracy M, Kipps, Thomas J, Messmer, Davorka
Formato: Artigo
Lenguaje:Inglês
Publicado: ScholarOne 2011
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269641/
https://ncbi.nlm.nih.gov/pubmed/21979753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00164
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