Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib

The chemokine CXCL12, via its receptor CXCR4, promotes increased survival of chronic lymphocytic leukemia (CLL) B cells that express high levels of ζ-chain–associated protein (ZAP-70), a receptor tyrosine kinase associated with aggressive disease. In this study, we investigated the underlying molecu...

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Detalhes bibliográficos
Main Authors: Messmer, Davorka, Fecteau, Jessie-F., O'Hayre, Morgan, Bharati, Ila S., Handel, Tracy M., Kipps, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035080/
https://ncbi.nlm.nih.gov/pubmed/21079155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-282400
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