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Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies
Patients suffering from acute myeloid leukemias (AML) bearing FMS-like tyrosine kinase-3-internal tandem duplications (FLT3-ITD) have poor outcomes following cytarabine- and anthracyclin-based induction therapy. To a major part this is attributed to drug resistance of FLT3-ITD-positive leukemic cell...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3317524/ https://ncbi.nlm.nih.gov/pubmed/22829255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2012.5 |
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