Synergistic cytotoxicity of sorafenib with busulfan and nucleoside analogs in human FLT3-ITD-positive acute myeloid leukemia cells

Clofarabine (Clo), fludarabine (Flu), and busulfan (Bu) are used in pre-transplant conditioning therapy for patients with myeloid leukemia. To further improve their efficacy in FLT3-ITD-positive AML, we investigated their synergism with sorafenib (Sor). Exposure of FLT3-ITD-positive MV-4-11 and MOLM...

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Publicado en:Biol Blood Marrow Transplant
Autores principales: Song, Guiyun, Valdez, Benigno C., Li, Yang, Liu, Yan, Champlin, Richard E., Andersson, Borje S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002996/
https://ncbi.nlm.nih.gov/pubmed/25111583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2014.08.003
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