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The histone deacetylase inhibitor SAHA sensitizes acute myeloid leukemia cells to a combination of nucleoside analogs and the DNA-alkylating agent busulfan

Fludarabine (Flu), clofarabine (Clo) and busulfan (Bu) are used in allogeneic hematopoietic stem cell transplant (allo-HSCT). We reported that combining [Flu + Clo + Bu] had a synergistic cytotoxicity in AML cells. We hypothesized that combining [Flu + Clo + Bu] with the histone deacetylase inhibito...

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Bibliografske podrobnosti
izdano v:Leuk Lymphoma
Main Authors: Song, Guiyun, Valdez, Benigno C., Li, Yang, Dominguez, Jose R., Corn, Paul, Champlin, Richard E., Andersson, Borje S.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320642/
https://ncbi.nlm.nih.gov/pubmed/24144307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2013.856007
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