Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies

Patients suffering from acute myeloid leukemias (AML) bearing FMS-like tyrosine kinase-3-internal tandem duplications (FLT3-ITD) have poor outcomes following cytarabine- and anthracyclin-based induction therapy. To a major part this is attributed to drug resistance of FLT3-ITD-positive leukemic cell...

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Autors principals: Kasper, S, Breitenbuecher, F, Heidel, F, Hoffarth, S, Markova, B, Schuler, M, Fischer, T
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317524/
https://ncbi.nlm.nih.gov/pubmed/22829255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2012.5
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