FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD–specific STAT5 activation

Myeloid cell leukemia-1 (MCL-1) is an essential survival factor for hematopoiesis. In humans, hematopoietic stem cells (HSCs) express MCL-1 at the highest level in response to FMS-like tyrosine kinase-3 (FLT3) signaling. We here show that this FLT3-dependent stem cell maintenance system also plays a...

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Detalhes bibliográficos
Main Authors: Yoshimoto, Goichi, Miyamoto, Toshihiro, Jabbarzadeh-Tabrizi, Siamak, Iino, Tadafumi, Rocnik, Jennifer L., Kikushige, Yoshikane, Mori, Yasuo, Shima, Takahiro, Iwasaki, Hiromi, Takenaka, Katsuto, Nagafuji, Koji, Mizuno, Shin-ichi, Niiro, Hiroaki, Gilliland, Gary D., Akashi, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788977/
https://ncbi.nlm.nih.gov/pubmed/19808698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-196055
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