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Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
Acquired mutations in the FLT3 receptor tyrosine kinase are common in acute myeloid leukemia and result in constitutive activation. The most frequent mechanism of activation is disruption of the juxtamembrane autoregulatory domain by internal tandem duplications (ITDs). FLT3-ITDs confer factor-indep...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society of Hematology
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895880/ https://ncbi.nlm.nih.gov/pubmed/16627759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-011429 |
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