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Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin
Small molecule inhibitors that target fms-like tyrosine kinase 3 (FLT3)–activating mutations have potential in the treatment of leukemias. However, certain mutations can simultaneously activate the tyrosine kinase, and confer resistance to small molecule inhibitors. We therefore tested the sensitivi...
Sparad:
| Huvudupphovsmän: | , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society of Hematology
2007
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234789/ https://ncbi.nlm.nih.gov/pubmed/17827387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-101238 |
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