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Mitotic chromosomes are constrained by topoisomerase II–sensitive DNA entanglements
We have analyzed the topological organization of chromatin inside mitotic chromosomes. We show that mitotic chromatin is heavily self-entangled through experiments in which topoisomerase (topo) II is observed to reduce mitotic chromosome elastic stiffness. Single chromosomes were relaxed by 35% by e...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835934/ https://ncbi.nlm.nih.gov/pubmed/20194637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200910085 |
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