Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse

NK cell cytotoxicity requires the formation of an actin-rich immunological synapse (IS) with a target cell and the polarization of perforin-containing lytic granules toward the IS. Following the polarization of lytic granules, they traverse through the actin-rich IS to join the NK cell membrane in o...

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Main Authors: Sanborn, Keri B., Rak, Gregory D., Maru, Saumya Y., Demers, Korey, Difeo, Analisa, Martignetti, John A, Betts, Michael R., Favier, Rémi, Banerjee, Pinaki P., Orange, Jordan S.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835774/
https://ncbi.nlm.nih.gov/pubmed/19454694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804337
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