UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion

NK cell’s killing is a tightly regulated process under the control of specific cytoskeletal proteins. This includes Wiskott-Aldrich-Syndrome protein, Wiskott-Aldrich-Syndrome protein-interacting protein, cofilin, Munc13-4, and nonmuscle myosin IIA (NMIIA). These proteins play a key role in controlli...

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Vydáno v:J Immunol
Hlavní autoři: Iizuka, Yoshie, Cichocki, Frank, Sieben, Andrew, Sforza, Fabio, Karim, Razaul, Coughlin, Kathleen, Vogel, Rachel Isaksson, Gavioli, Riccardo, McCullar, Valarie, Lenvik, Todd, Lee, Michael, Miller, Jeffrey, Bazzaro, Martina
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5189640/
https://ncbi.nlm.nih.gov/pubmed/26438524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500979
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