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Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells

The molecular basis for the different roles of IL-2 and IL-15 in lymphocyte function has been poorly defined. Searching for differences that underlie the distinct T cell responses to the two cytokines, we observed a marked susceptibility of the IL-15-induced but not of the IL-2-induced proliferation...

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Detalhes bibliográficos
Main Authors: Dubois, Sigrid, Shou, Weinian, Haneline, Laura S., Fleischer, Sidney, Waldmann, Thomas A., Müller, Jürgen R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC283564/
https://ncbi.nlm.nih.gov/pubmed/14605212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2335979100
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