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ITK and IL-15 support two distinct subsets of CD8(+) T cells

CD8(+) T cells are commonly divided into naïve CD44(lo)CD122(lo) and “memory phenotype” CD44(hi)CD122(hi) cells. Here we show data suggesting that these two cell populations represent independent CD8(+) T cell subsets. Whereas IL-15(−/−) mice lack CD44(hi)CD122(hi) CD8(+) T cells, mice deficient in...

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Autori principali: Dubois, Sigrid, Waldmann, Thomas A., Müller, Jürgen R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567699/
https://ncbi.nlm.nih.gov/pubmed/16880398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605212103
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