Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin

Although the tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO), is a pivotal mediator of inflammation-induced depression, its mechanism of regulation has not yet been investigated in this context. Here, we demonstrate an essential role for interferon (IFN)γ and tumor necrosis factor (TN...

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Bibliografiset tiedot
Päätekijät: O'Connor, Jason C., André, Caroline, Wang, Yunxia, Lawson, Marcus A., Szegedi, Sandra S., Lestage, Jacques, Castanon, Nathalie, Kelley, Keith W., Dantzer, Robert
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2009
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835569/
https://ncbi.nlm.nih.gov/pubmed/19339614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5032-08.2009
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