Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease

Neprilysin (NEP) is a zinc metallopeptidase that efficiently degrades the amyloid β (Aβ) peptides believed to be involved in the etiology of Alzheimer disease (AD). The focus of this study was to develop a new and tractable therapeutic approach for treating AD using NEP gene therapy. We have introdu...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Liu, Yinxing, Studzinski, Christa, Beckett, Tina, Guan, Hanjun, Hersh, Matthew A, Murphy, M Paul, Klein, Ronald, Hersh, Louis B
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2009
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835241/
https://ncbi.nlm.nih.gov/pubmed/19471248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.115
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares