Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease

Neprilysin (NEP) is a zinc metallopeptidase that efficiently degrades the amyloid β (Aβ) peptides believed to be involved in the etiology of Alzheimer disease (AD). The focus of this study was to develop a new and tractable therapeutic approach for treating AD using NEP gene therapy. We have introdu...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Yinxing, Studzinski, Christa, Beckett, Tina, Guan, Hanjun, Hersh, Matthew A, Murphy, M Paul, Klein, Ronald, Hersh, Louis B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835241/
https://ncbi.nlm.nih.gov/pubmed/19471248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.115
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