Asymmetric Shorter-duplex siRNA Structures Trigger Efficient Gene Silencing With Reduced Nonspecific Effects

Small interfering RNAs (siRNAs) are short, double-stranded RNAs that mediate efficient gene silencing in a sequence-specific manner by utilizing the endogenous RNA interference (RNAi) pathway. The current standard synthetic siRNA structure harbors a 19–base-pair duplex region with 3′ overhangs of 2...

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Bibliographische Detailangaben
Hauptverfasser: Chang, Chan Il, Yoo, Jae Wook, Hong, Sun Woo, Lee, Shi Eun, Kang, Hye Suk, Sun, Xiangao, Rogoff, Harry A, Ban, Changill, Kim, Soyoun, Li, Chiang J, Lee, Dong-ki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835116/
https://ncbi.nlm.nih.gov/pubmed/19156133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.298
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