Long-term Transgene Expression in the Central Nervous System Using DNA Nanoparticles

This study demonstrates proof of concept for delivery and expression of compacted plasmid DNA in the central nervous system. Plasmid DNA was compacted with polyethylene glycol substituted lysine 30-mer peptides, forming rod-like nanoparticles with diameters between 8 and 11 nm. Here we show that an...

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Autores principales: Yurek, David M, Fletcher, Anita M, Smith, George M, Seroogy, Kim B, Ziady, Assem G, Molter, Joseph, Kowalczyk, Tomasz H, Padegimas, Linas, Cooper, Mark J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2009
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835115/
https://ncbi.nlm.nih.gov/pubmed/19223866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.2
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