Long-term Transgene Expression in the Central Nervous System Using DNA Nanoparticles

This study demonstrates proof of concept for delivery and expression of compacted plasmid DNA in the central nervous system. Plasmid DNA was compacted with polyethylene glycol substituted lysine 30-mer peptides, forming rod-like nanoparticles with diameters between 8 and 11 nm. Here we show that an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yurek, David M, Fletcher, Anita M, Smith, George M, Seroogy, Kim B, Ziady, Assem G, Molter, Joseph, Kowalczyk, Tomasz H, Padegimas, Linas, Cooper, Mark J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835115/
https://ncbi.nlm.nih.gov/pubmed/19223866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.2
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