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Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor (hGDNF)
A goal of our studies is to develop a potential therapeutic for Parkinson’s disease (PD) by a human GDNF (hGDNF) expression plasmid administered to the rat striatum as a compacted DNA nanoparticle (DNP) and which will generate long-term hGDNF expression at biologically active levels. In the present...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3408714/ https://ncbi.nlm.nih.gov/pubmed/21839809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2011.07.072 |
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