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Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor (hGDNF)

A goal of our studies is to develop a potential therapeutic for Parkinson’s disease (PD) by a human GDNF (hGDNF) expression plasmid administered to the rat striatum as a compacted DNA nanoparticle (DNP) and which will generate long-term hGDNF expression at biologically active levels. In the present...

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Autores principales: Fletcher, Anita M., Kowalczyk, Tomasz H., Padegimas, Linas, Cooper, Mark J., Yurek, David M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408714/
https://ncbi.nlm.nih.gov/pubmed/21839809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2011.07.072
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