ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA

Stable addition of U2 small nuclear ribonucleoprotein (snRNP) to form the prespliceosome is the first ATP-dependent step in splicing, and it requires the DEXD/H box ATPase Prp5p. However, prespliceosome formation occurs without ATP in extracts lacking the U2 snRNP protein Cus2p. Here we show that Pr...

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Bibliographic Details
Main Authors: Perriman, Rhonda, Barta, Imre, Voeltz, Gia K., Abelson, John, Ares, Manuel
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC283511/
https://ncbi.nlm.nih.gov/pubmed/14610285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2036312100
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