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Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing

Nuclear pre-messenger RNA (pre-mRNA) splicing requires multiple spliceosomal small nuclear RNA (snRNA) and pre-mRNA rearrangements. Here we reveal a new snRNA conformational switch in which successive roles for two competing U2 helices, stem IIa and stem IIc, promote distinct splicing steps. When st...

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Detalhes bibliográficos
Main Authors: Perriman, Rhonda J., Ares, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838532/
https://ncbi.nlm.nih.gov/pubmed/17403781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1524307
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