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Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing
Nuclear pre-messenger RNA (pre-mRNA) splicing requires multiple spliceosomal small nuclear RNA (snRNA) and pre-mRNA rearrangements. Here we reveal a new snRNA conformational switch in which successive roles for two competing U2 helices, stem IIa and stem IIc, promote distinct splicing steps. When st...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1838532/ https://ncbi.nlm.nih.gov/pubmed/17403781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1524307 |
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