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A high throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes
The spliceosome is the macromolecular machine responsible for pre-mRNA splicing, an essential step in eukaryotic gene expression. During splicing a myriad of subunits join and leave the spliceosome as it works on the pre-mRNA substrate. Strikingly, there are very few small molecules known to interac...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3902173/ https://ncbi.nlm.nih.gov/pubmed/23771823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057113493117 |
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