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ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA
Stable addition of U2 small nuclear ribonucleoprotein (snRNP) to form the prespliceosome is the first ATP-dependent step in splicing, and it requires the DEXD/H box ATPase Prp5p. However, prespliceosome formation occurs without ATP in extracts lacking the U2 snRNP protein Cus2p. Here we show that Pr...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC283511/ https://ncbi.nlm.nih.gov/pubmed/14610285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2036312100 |
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