Transcription-dependent degradation controls the stability of the SREBP family of transcription factors
Cholesterol metabolism is tightly controlled by members of the sterol regulatory element-binding protein (SREBP) family of transcription factors. Here we demonstrate that the ubiquitination and degradation of SREBPs depend on their transcriptional activity. Mutations in the transactivation or DNA-bi...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14615581/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2335135100 |
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