The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53

The transcription coactivator p300 cannot acetylate native p53 tetramers, thus revealing intrinsic conformational constraints on p300-catalyzed acetylation. Consensus site DNA is an allosteric effector that promotes acetylation of p53, suggesting that p300 has an undefined conformationally flexible...

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Detalhes bibliográficos
Main Authors: Dornan, David, Shimizu, Harumi, Burch, Lindsay, Smith, Amanda J., Hupp, Ted R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262654/
https://ncbi.nlm.nih.gov/pubmed/14612423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.23.8846-8861.2003
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