The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53

The transcription coactivator p300 cannot acetylate native p53 tetramers, thus revealing intrinsic conformational constraints on p300-catalyzed acetylation. Consensus site DNA is an allosteric effector that promotes acetylation of p53, suggesting that p300 has an undefined conformationally flexible...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Dornan, David, Shimizu, Harumi, Burch, Lindsay, Smith, Amanda J., Hupp, Ted R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	Transcriptional Regulation
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262654/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14612423/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.23.8846-8861.2003
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