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Transcription-dependent degradation controls the stability of the SREBP family of transcription factors

Cholesterol metabolism is tightly controlled by members of the sterol regulatory element-binding protein (SREBP) family of transcription factors. Here we demonstrate that the ubiquitination and degradation of SREBPs depend on their transcriptional activity. Mutations in the transactivation or DNA-bi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sundqvist, Anders, Ericsson, Johan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC283507/
https://ncbi.nlm.nih.gov/pubmed/14615581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2335135100
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