Transcription-dependent degradation controls the stability of the SREBP family of transcription factors
Cholesterol metabolism is tightly controlled by members of the sterol regulatory element-binding protein (SREBP) family of transcription factors. Here we demonstrate that the ubiquitination and degradation of SREBPs depend on their transcriptional activity. Mutations in the transactivation or DNA-bi...
Salvato in:
| Pubblicato in: | Proc Natl Acad Sci U S A |
|---|---|
| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14615581/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2335135100 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|